Endocrine Abstracts

Background: Serum thyroglobulin (Tg) is a reliable tumor marker in patients with differentiated thyroid carcinoma (DTC). Distant metastases of DTC, particularly in the lung, normally presents with higher levels of Tg, which is useful to follow the disease evolution. We describe a patient with DTC with lung metastases, with undetectable Tg and Tg-antibodies (TgAb).Clinical case: A 52-year-old woman underwent a subtotal thyroidectomy in 1993 because of a g...

Introduction: Identification of molecular markers with a reliable prognostic value may greatly improve the management of patients with papillary thyroid carcinoma (PTC). Rac1b, a hyperactive splice variant of the small GTPase Rac1, was found to be overexpressed in colorectal, breast and lung cancer. It has been shown to sustain tumor cell survival in colorectal cancer and was reported to have a key role in the malignant progression of breast and lung tumors. The Rac1b tumorige...

Introduction: Forkhead box E1 (FOXE1) gene encodes a transcription factor crucial for thyroid morphogenesis, differentiation, and function. We previously found evidence of the involvement of a rare germline FOXE1 variant in familial non-medullary thyroid carcinoma (FNMTC) etiology. FNMTC most common subtype is papillary thyroid carcinoma (PTC), and family members frequently present thyroid follicular nodular disease (FND). Germline FOXE1 mu...